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KMID : 0359819930220101057
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Journal of Korean Neurosurgical Society
1993 Volume.22 No. 10 p.1057 ~ p.1063
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The Effects of Acetazolamide and Fluphenazin on CSF Formation
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송준혁
박윤관/정홍섭/서중근/이훈갑/이기찬/주정화
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Abstract
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The purpose of this study was to investigate the effect of acetazolamide and fluphenazine on the formation of CSF. Studies were performed in 12 cats those were divided into 2 groups ; A-F group included animals received initial acetazolamide
infusion
and additional infusion of fluphenazine to the initial infusion and the F-A group for vice versa.
The rate of CSF formation was measured at 3cm above zero ouflow pressure by force transducer which connected to personal computer. After obtaining steady value of CSF formation rate. 18.87±6.52μl/min. is reduced to 6.67±2.45μl/min after
acetazolamide infusion and further reduced to 3.48±4.06μl/min after additional fluphenazine. In fluphenazine group, the base line CSF formation rate. 16.34±4.58μl/min is reduced to 9.63±4.58μl/min after initial infusion of fluphenazine and
further
to 6.45±3.64μl/min. after additional infusion of acetazolemide. Mean reduction of CSF formation after initial intravenous infusion of acetazolamide and fluphenazine were 59% and 37% respectively. Although statistically insignificant, the CSF
lormation
reduction in A-F group revealed more even and profound value comparing with that of F-A group. These date suggest that in addition ot the effect of acetazolamide to reduce the formation of CSF, some other mechanism may exist in CSF formation that
major
tranquilizer exert the effect on CSF formation.
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KEYWORD
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